Assignment 18: Annotated Bibliography 2
Source
Zi-Chen, Hao, et al. "Stem Cell Therapy: A Promising Biological Strategy for Tendon Bone Healing After Anterior Cruciate Ligament Reconstruction." Cell Proliferation, vol. 49, no. 2, Apr. 2016, pp. 154-162. EBSCOhost, doi:10.1111/cpr.12242.
Summary
The ACL tear is a common injury among athletes affecting “1 in 3000 in the United States.” (Hao 154) The most common resolution to the ACL tear is taking a graft of tendon from a nearby structure such as the hamstring or patella. This method, however, has proven to fail. Because of the excess fibrous scar tissue that forms after surgery, the recovery timeline is delayed. A new method using stem cells is being tested in tendon to bone healing in hopes that the road to recovery will be quicker and yield stronger muscles. Future studies and clinical data is needed to confirm the hypothesis that stem cells are beneficial to the recovering process after ACL reconstruction surgery.
Potential Quotes
Examples of quotes that will be beneficial and factual for the paper include:
“ACL rupture is a common sports injury with a preva- lence estimated to be 1 in 3000 in the United States. It may result in a spectrum of secondary symptoms, including knee laxity, movement dysfunction, meniscus and cartilage damage and even early post-traumatic osteoarthritis, which exerts a heavy burden on the patients and impact heavily on the society.”
“The interface between the transplanted tendon and the bone tunnel usually heals with a fibrous scar tissue rather than a natural insertion in a few months, failing to restore the normal joint kine- matics and kinetics (25–30). As a consequence, rehabili- tation programme has to be delayed”
“Among these treatments, stem cells derived from multiple tissues, such as bMSCs (51–54) and synovial MSCs (sMSCs) (55) have been demonstrated promising potential in pro- moting tendon–bone healing. Recently, CD34+ stem cells from ACL tissues have presented admirable perfor- mance on tendon–bone healing (56–58).”
Assessment of Source
This article was published recently within the last two years. It has been revised so that the information is up to date. The article was written by a group of doctors studying at Southeast University in China. They are working alongside the Research center as a part of medical school. By being a part of a research center, they have credible evidence to support their claim about stem cells being used in ACL reconstruction.
Reflection
This article is applicable to my essential question and is a prime example of how the medical field is constantly changing. If the stem cell ACL reconstruction surgery is successful, this will completely alter a normal physical therapy plan for athletes returning from the injury. As research yields new and improved data, physical therapist are having to change the way in which they address recovery plans. While this article doesn't explain how a physical therapist will have to treat patients with the stem cell surgery, it does illustrate how the medical field will continue to discover new ways to become efficient.